PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α

Tumor cell resistance to ionizing radiation and chemotherapy is a major obstacle in cancer therapy. One factor contributing to this is integrin-mediated adhesion to ECM. The adapter protein particularly interesting new cysteine-histidine-rich 1 (PINCH1) is recruited to integrin adhesion sites and pr...

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Hlavní autoři: Eke, Iris, Koch, Ulrike, Hehlgans, Stephanie, Sandfort, Veit, Stanchi, Fabio, Zips, Daniel, Baumann, Michael, Shevchenko, Anna, Pilarsky, Christian, Haase, Michael, Baretton, Gustavo B., Calleja, Véronique, Larijani, Banafshé, Fässler, Reinhard, Cordes, Nils
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898588/
https://ncbi.nlm.nih.gov/pubmed/20530873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41078
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