7,3′,4′-Trihydroxyisoflavone Inhibits Epidermal Growth Factor-induced Proliferation and Transformation of JB6 P+ Mouse Epidermal Cells by Suppressing Cyclin-dependent Kinases and Phosphatidylinositol 3-Kinase

Numerous in vitro and in vivo studies have shown that isoflavones exhibit anti-proliferative activity against epidermal growth factor (EGF) receptor-positive malignancies of the breast, colon, skin, and prostate. 7,3′,4′-Trihydroxyisoflavone (7,3′,4′-THIF) is one of the metabolites of daidzein, a we...

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Main Authors: Lee, Dong Eun, Lee, Ki Won, Song, Nu Ry, Seo, Sang Kwon, Heo, Yong-Seok, Kang, Nam Joo, Bode, Ann M., Lee, Hyong Joo, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898435/
https://ncbi.nlm.nih.gov/pubmed/20444693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094797
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