Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria: POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS

The transcriptional co-activator PGC-1α and the NAD(+)-dependent deacetylase SIRT1 are considered important inducers of mitochondrial biogenesis because in the nucleus they regulate transcription of nucleus-encoded mitochondrial genes. We demonstrate that PGC-1α and SIRT1 are also present inside mit...

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Detalhes bibliográficos
Main Authors: Aquilano, Katia, Vigilanza, Paola, Baldelli, Sara, Pagliei, Beatrice, Rotilio, Giuseppe, Ciriolo, Maria Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898414/
https://ncbi.nlm.nih.gov/pubmed/20448046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070169
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