Mice Deficient in N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Are Unable to Synthesize Chondroitin/Dermatan Sulfate containing N-Acetylgalactosamine 4,6-Bissulfate Residues and Exhibit Decreased Protease Activity in Bone Marrow-derived Mast Cells

Chondroitin sulfate (CS) and dermatan sulfate (DS) containing N-acetylgalactosamine 4,6-bissulfate (GalNAc(4,6-SO(4))) show various physiological activities through interacting with numerous functional proteins. N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate fr...

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Main Authors: Ohtake-Niimi, Shiori, Kondo, Sachiko, Ito, Tatsuro, Kakehi, Saori, Ohta, Tadayuki, Habuchi, Hiroko, Kimata, Koji, Habuchi, Osami
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898370/
https://ncbi.nlm.nih.gov/pubmed/20439988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.084749
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