Valproate Treatment of Human Cord Blood CD4-positive Effector T Cells Confers on Them the Molecular Profile (MicroRNA Signature and FOXP3 Expression) of Natural Regulatory CD4-positive Cells through Inhibition of Histone Deacetylase

Regulatory T cells (Tregs) play a key role in immune system homeostasis and tolerance to antigens, thereby preventing autoimmunity, and may be partly responsible for the lack of an appropriate immune response against tumor cells. Although not sufficient, a high expression of forkhead box P3 (FOXP3)...

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Detalhes bibliográficos
Main Authors: Fayyad-Kazan, Hussein, Rouas, Redouane, Merimi, Makram, El Zein, Nabil, Lewalle, Philippe, Jebbawi, Fadi, Mourtada, Mohamad, Badran, Hussein, Ezzeddine, Mohamad, Salaun, Bruno, Romero, Pedro, Burny, Arsène, Martiat, Philippe, Badran, Bassam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898312/
https://ncbi.nlm.nih.gov/pubmed/20427269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.119628
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