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TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

Somatosensory neurons detect environmental stimuli, converting external cues into neural activity that is relayed first to second-order neurons in the spinal cord. The detection of cold is proposed to be mediated by the ion channels TRPM8 and TRPA1. However, there is significant debate regarding the...

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Bibliografiske detaljer
Main Authors: Knowlton, Wendy M., Fisher, Amber, Bautista, Diana M., McKemy, David D.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897947/
https://ncbi.nlm.nih.gov/pubmed/20542379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2010.05.021
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