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Mechanistic and Signaling Analysis of Muc4-ErbB2 Signaling Module: New Insights into the Mechanism of Ligand-Independent ErbB2 Activity

The membrane mucin Muc4 is aberrantly expressed in numerous epithelial carcinomas and is currently used as a cancer diagnostic and prognostic tool. Muc4 can also potentiate signal transduction by modulating differential ErbB2 phosphorylation in the absence and in the presence of the ErbB3 soluble li...

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Detalhes bibliográficos
Main Authors: Kozloski, Goldi A., Carothers Carraway, Coralie A., Carraway, Kermit L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897936/
https://ncbi.nlm.nih.gov/pubmed/20432461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22163
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