Activation of GPR30 inhibits growth of prostate cancer cells via sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G2 cell-cycle arrest

G protein–coupled receptor 30 (GPR30) exhibits estrogen-binding affinity and mediates nongenomic signaling of estrogen to regulate cell growth. We here demonstrated for the first time, in contrast to the reported promoting action of GPR30 on the growth of breast and ovarian cancer cells, that activa...

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Autores principales: Chan, Queeny K.Y., Lam, Hung-Ming, Ng, Chi-Fai, Lee, Amy Y.Y., Chan, Eddie S.Y., Ng, Ho-Keung, Ho, Shuk-Mei, Lau, Kin-Mang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897932/
https://ncbi.nlm.nih.gov/pubmed/20203690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.20
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