Paradoxical Role of Prion Protein Aggregates in Redox-Iron Induced Toxicity

BACKGROUND: Imbalance of iron homeostasis has been reported in sporadic Creutzfeldt-Jakob-disease (sCJD) affected human and scrapie infected animal brains, but the contribution of this phenotype to disease associated neurotoxicity is unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using cell models of fami...

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Autori principali: Das, Dola, Luo, Xiu, Singh, Ajay, Gu, Yaping, Ghosh, Soumya, Mukhopadhyay, Chinmay K., Chen, Shu G., Sy, Man-Sun, Kong, Qingzhong, Singh, Neena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897850/
https://ncbi.nlm.nih.gov/pubmed/20625431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011420
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