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Using a conformation-dependent stereochemical library improves crystallographic refinement of proteins

The major macromolecular crystallographic refinement packages restrain models to ideal geometry targets defined as single values that are independent of molecular conformation. However, ultrahigh-resolution X-ray models of proteins are not consistent with this concept of ideality and have been used...

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Autori principali: Tronrud, Dale E., Berkholz, Donald S., Karplus, P. Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897700/
https://ncbi.nlm.nih.gov/pubmed/20606264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910019207
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