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The N Terminus of Adenovirus Type 12 E1A Inhibits Major Histocompatibility Complex Class I Expression by Preventing Phosphorylation of NF-κB p65 Ser(276) through Direct Binding
The immune-escape strategy employed by human oncogenic adenovirus type 12 (Ad12) involves downregulation of major histocompatibility complex class I (MHC-I) transcription by disabling the transactivator NF-κB (p50/p65). This is accomplished by the Ad12 E1A protein (E1A-12), which prevents NF-κB from...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2897633/ https://ncbi.nlm.nih.gov/pubmed/20504937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02317-09 |
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