Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

HIV/AIDS continues to be a menace to public health. Several drugs currently on the market have successfully improved the ability to manage the viral burden in infected patients. However, new drugs are needed to combat the rapid emergence of mutated forms of the virus that are resistant to existing t...

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Main Authors: Su, Hua-Poo, Yan, Youwei, Prasad, G. Sridhar, Smith, Robert F., Daniels, Christopher L., Abeywickrema, Pravien D., Reid, John C., Loughran, H. Marie, Kornienko, Maria, Sharma, Sujata, Grobler, Jay A., Xu, Bei, Sardana, Vinod, Allison, Timothy J., Williams, Peter D., Darke, Paul L., Hazuda, Daria J., Munshi, Sanjeev
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897604/
https://ncbi.nlm.nih.gov/pubmed/20484498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00353-10
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