A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

In response to stress, cells can utilize several cellular processes, such as autophagy, which is a bulk-lysosomal degradation pathway, to mitigate damages and increase the chances of cell survival. Deregulation of autophagy causes upregulation of p62 and the formation of p62-containing aggregates, w...

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Bibliografiske detaljer
Main Authors: Lau, Alexandria, Wang, Xiao-Jun, Zhao, Fei, Villeneuve, Nicole F., Wu, Tongde, Jiang, Tao, Sun, Zheng, White, Eileen, Zhang, Donna D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897585/
https://ncbi.nlm.nih.gov/pubmed/20421418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00248-10
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