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Clinical and Toxicodynamic Evidence that High-Dose Pyrazinamide Is Not More Hepatotoxic than the Low Doses Currently Used

Antimicrobial pharmacokinetic-pharmacodynamic studies suggest that pyrazinamide doses higher than those currently recommended may be more efficacious. However, high pyrazinamide doses are believed to be hepatotoxic. Searches for clinical trials in MEDLINE, EBSCOHOST, and the Cochrane Controlled Tria...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Pasipanodya, Jotam G., Gumbo, Tawanda
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897291/
https://ncbi.nlm.nih.gov/pubmed/20439617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01567-09
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