Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and...

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Bibliographic Details
Main Authors: Furihata, Tomomi, Fukuchi, Yukina, Iikura, Minami, Hashizume, Misato, Miyajima, Atsushi, Nagai, Miki, Chiba, Kan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897278/
https://ncbi.nlm.nih.gov/pubmed/20421393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00010-10
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