Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes

Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions. The results of our study showed that mouse hepatocytes hardly expressed CNT2 mRNA and...

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Autores principales: Furihata, Tomomi, Fukuchi, Yukina, Iikura, Minami, Hashizume, Misato, Miyajima, Atsushi, Nagai, Miki, Chiba, Kan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2010
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897278/
https://ncbi.nlm.nih.gov/pubmed/20421393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00010-10
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