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Impaired Immunogenicity of a Meningococcal Factor H-Binding Protein Vaccine Engineered To Eliminate Factor H Binding

Meningococcal factor H-binding protein (fHbp) is a promising antigen that is part of two vaccines in clinical development. The protein specifically binds human complement factor H (fH), which downregulates complement activation on the bacterial surface and enables the organism to evade host defenses...

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Autors principals: Beernink, Peter T., Shaughnessy, Jutamas, Ram, Sanjay, Granoff, Dan M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897264/
https://ncbi.nlm.nih.gov/pubmed/20519444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00103-10
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