A Histoplasma capsulatum-Specific IgG1 Isotype Monoclonal Antibody, H1C, to a 70-Kilodalton Cell Surface Protein Is Not Protective in Murine Histoplasmosis

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further dem...

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Bibliografiske detaljer
Main Authors: Lopes, Livia Cristina Liporagi, Guimarães, Allan J., de Cerqueira, Mariana Duarte, Gómez, Beatriz L., Nosanchuk, Joshua D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Immune Mechanisms
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897255/
https://ncbi.nlm.nih.gov/pubmed/20484567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00033-10
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