Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

BACKGROUND: Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1 (HIF-1) play a key role in glioma invasion. RESULTS: To...

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Detalhes bibliográficos
Main Authors: Méndez, Olga, Zavadil, Jiri, Esencay, Mine, Lukyanov, Yevgeniy, Santovasi, Daniel, Wang, Shu-Chi, Newcomb, Elizabeth W, Zagzag, David
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896954/
https://ncbi.nlm.nih.gov/pubmed/20515450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-133
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