Mathematical modeling of chimeric TCR triggering predicts the magnitude of target lysis and its impairment by TCR down-modulation

We investigated relationships among chimeric T cell receptor (cTCR) expression density, target antigen density, and cTCR triggering to predict lysis of target cells by cTCR(+) CD8(+) T human cells as a function of antigen density. Triggering of chimeric and canonical TCR by antigen could be quantifi...

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Main Authors: James, Scott E., Greenberg, Philip D., Jensen, Michael C., Lin, Yukang, Wang, Jinjuan, Budde, Lihua E., Till, Brian G., Raubitschek, Andrew A., Forman, Stephen J., Press, Oliver W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896691/
https://ncbi.nlm.nih.gov/pubmed/20220093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903701
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