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Somatic expression of LINE-1 elements in human tissues
LINE-1 expression damages host DNA via insertions and endonuclease-dependent DNA double-strand breaks (DSBs) that are highly toxic and mutagenic. The predominant tissue of LINE-1 expression has been considered to be the germ line. We show that both full-length and processed L1 transcripts are widesp...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896524/ https://ncbi.nlm.nih.gov/pubmed/20215437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq132 |
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