The Structures of the Thrombospondin-1 N-Terminal Domain and Its Complex with a Synthetic Pentameric Heparin

The N-terminal domain of thrombospondin-1 (TSPN-1) mediates the protein’s interaction with (1) glycosaminoglycans, calreticulin, and integrins during cellular adhesion, (2) low-density lipoprotein receptor-related protein during uptake and clearance, and (3) fibrinogen during platelet aggregation. T...

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Bibliographic Details
Main Authors: Tan, Kemin, Duquette, Mark, Liu, Jin-huan, Zhang, Rongguang, Joachimiak, Andrzej, Wang, Jia-huai, Lawler, Jack
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896259/
https://ncbi.nlm.nih.gov/pubmed/16407063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2005.09.017
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