Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Entry Factors

Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR-BI), CD81, claudin-1 and occludin. Among these, at least CD81 and occludin a...

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Hauptverfasser: Bitzegeio, Julia, Bankwitz, Dorothea, Hueging, Kathrin, Haid, Sibylle, Brohm, Christiane, Zeisel, Mirjam B., Herrmann, Eva, Iken, Marcus, Ott, Michael, Baumert, Thomas F., Pietschmann, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895659/
https://ncbi.nlm.nih.gov/pubmed/20617177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000978
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