Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes

The variability of the hepatitis C virus (HCV), which likely contributes to immune escape, is most pronounced in hypervariable region 1 (HVR1) of viral envelope protein 2. This domain is the target for neutralizing antibodies, and its deletion attenuates replication in vivo. Here we characterized th...

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Main Authors: Bankwitz, Dorothea, Steinmann, Eike, Bitzegeio, Julia, Ciesek, Sandra, Friesland, Martina, Herrmann, Eva, Zeisel, Mirjam B., Baumert, Thomas F., Keck, Zhen-yong, Foung, Steven K. H., Pécheur, Eve-Isabelle, Pietschmann, Thomas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876602/
https://ncbi.nlm.nih.gov/pubmed/20357091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02200-09
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