Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on apposed cell surfaces plays important roles in development and exhibits poorly understood functional alterations in cancer. We reconstituted this intermembrane signaling geometry between live EphA2-expressing human br...

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Bibliographic Details
Main Authors: Salaita, Khalid, Nair, Pradeep M., Petit, Rebecca S., Neve, Richard M., Das, Debopriya, Gray, Joe W., Groves, Jay T.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895569/
https://ncbi.nlm.nih.gov/pubmed/20223987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1181729
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