Desensitization of vascular response in vivo: Contribution of genetic variation in the alpha(2B)-adrenergic receptor subtype

OBJECTIVES: Vascular alpha(2B) adrenergic receptors (α(2B)-ARs) mediate vasoconstriction and contribute to peripheral regulation of vascular tone. In vitro, a common 301-303 deletion in the α(2B)-AR gene, ADRA2B, results in loss of α(2B)-AR desensitization. We examined the hypothesis that ADRA2B del...

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Detaylı Bibliyografya
Asıl Yazarlar: Muszkat, Mordechai, Kurnik, Daniel, Sofowora, Gbenga G., Solus, Joseph, Xie, Hong-Guang, Harris, Paul A., Williams, Scott M., Wood, Alastair J.J., Stein, C. Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895551/
https://ncbi.nlm.nih.gov/pubmed/20051907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328333d212
Etiketler: Etiketle
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