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The Potential Landscape of Genetic Circuits Imposes the Arrow of Time in Stem Cell Differentiation
Differentiation from a multipotent stem or progenitor state to a mature cell is an essentially irreversible process. The associated changes in gene expression patterns exhibit time-directionality. This “arrow of time” in the collective change of gene expression across multiple stable gene expression...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Biophysical Society
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2895388/ https://ncbi.nlm.nih.gov/pubmed/20655830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.058 |
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