The Potential Landscape of Genetic Circuits Imposes the Arrow of Time in Stem Cell Differentiation

Differentiation from a multipotent stem or progenitor state to a mature cell is an essentially irreversible process. The associated changes in gene expression patterns exhibit time-directionality. This “arrow of time” in the collective change of gene expression across multiple stable gene expression...

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Hlavní autoři: Wang, Jin, Xu, Li, Wang, Erkang, Huang, Sui
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2010
Témata:
Biological Systems and Multicellular Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895388/
https://ncbi.nlm.nih.gov/pubmed/20655830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.058
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