Mechanical Unfolding of Acylphosphatase Studied by Single-Molecule Force Spectroscopy and MD Simulations

Single-molecule manipulation methods provide a powerful means to study protein transitions. Here we combined single-molecule force spectroscopy and steered molecular-dynamics simulations to study the mechanical properties and unfolding behavior of the small enzyme acylphosphatase (AcP). We find that...

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Autors principals: Arad-Haase, Gali, Chuartzman, Silvia G., Dagan, Shlomi, Nevo, Reinat, Kouza, Maksim, Mai, Binh Khanh, Nguyen, Hung Tien, Li, Mai Suan, Reich, Ziv
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
Matèries:
Protein
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895382/
https://ncbi.nlm.nih.gov/pubmed/20655852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.004
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