Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing

Prestin is a member of the SLC26 family of anion transporters and is responsible for electromotility in outer hair cells, the basis of cochlear amplification in mammals. It is an anion transporting transmembrane protein, possessing nine cysteine residues, which generates voltage-dependent charge mov...

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Autors principals: Bai, Jun-Ping, Surguchev, Alexei, Bian, Shumin, Song, Lei, Santos-Sacchi, Joseph, Navaratnam, Dhasakumar
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2010
Matèries:
Cellular Biophysics and Electrophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895379/
https://ncbi.nlm.nih.gov/pubmed/20655836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.066
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