Combinatorial Cysteine Mutagenesis Reveals a Critical Intramonomer Role for Cysteines in Prestin Voltage Sensing

Prestin is a member of the SLC26 family of anion transporters and is responsible for electromotility in outer hair cells, the basis of cochlear amplification in mammals. It is an anion transporting transmembrane protein, possessing nine cysteine residues, which generates voltage-dependent charge mov...

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Bibliographic Details
Main Authors: Bai, Jun-Ping, Surguchev, Alexei, Bian, Shumin, Song, Lei, Santos-Sacchi, Joseph, Navaratnam, Dhasakumar
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2010
Subjects:
Cellular Biophysics and Electrophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895379/
https://ncbi.nlm.nih.gov/pubmed/20655836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.03.066
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