GABA(A) Receptor Alpha 4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane

BACKGROUND: General anesthesia produces multiple endpoints including immobility, hypnosis, sedation and amnesia. Tonic inhibition via γ–aminobutyric acid type A receptors (GABA(A)-Rs) may play a role in mediating behavioral endpoints that are suppressed by low concentrations of anesthetics (e.g., hy...

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Detalhes bibliográficos
Main Authors: Rau, Vinuta, Iyer, Sangeetha V., Oh, Irene, Chandra, Dev, Harrison, Neil, Eger, Edmond I, Fanselow, Michael S., Homanics, Gregg E., Sonner, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895314/
https://ncbi.nlm.nih.gov/pubmed/19923508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e3181bf6ae6
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