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Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

AV411 (ibudilast; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine) is an antiinflammatory drug that was initially developed for the treatment of bronchial asthma but which also has been used for cerebrovascular and ocular indications. It is a nonselective inhibitor of various phosphodiesterases (PD...

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Bibliografiske detaljer
Main Authors: Cho, Yoonsang, Crichlow, Gregg V., Vermeire, Jon J., Leng, Lin, Du, Xin, Hodsdon, Michael E., Bucala, Richard, Cappello, Michael, Gross, Matt, Gaeta, Federico, Johnson, Kirk, Lolis, Elias J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895110/
https://ncbi.nlm.nih.gov/pubmed/20534506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002716107
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