Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors

The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new pharmacophores. Hookworms are blood-feeding, intestinal nematode parasites that infect up to 600 million people worldwide. Vaccination with recombinant Ancylostoma ceyla...

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Bibliographische Detailangaben
Hauptverfasser: Cho, Yoonsang, Vermeire, Jon J., Merkel, Jane S., Leng, Lin, Du, Xin, Bucala, Richard, Cappello, Michael, Lolis, Elias
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294498/
https://ncbi.nlm.nih.gov/pubmed/21944748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.07.011
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