Protein-Protein Interaction Antagonists as Novel Inhibitors of Non-Canonical Polyubiquitylation

BACKGROUND: Several pathways that control cell survival under stress, namely RNF8-dependent DNA damage recognition and repair, PCNA-dependent DNA damage tolerance and activation of NF-κB by extrinsic signals, are regulated by the tagging of key proteins with lysine 63-based polyubiquitylated chains,...

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Main Authors: Scheper, Johanna, Guerra-Rebollo, Marta, Sanclimens, Glòria, Moure, Alejandra, Masip, Isabel, González-Ruiz, Domingo, Rubio, Nuria, Crosas, Bernat, Meca-Cortés, Óscar, Loukili, Noureddine, Plans, Vanessa, Morreale, Antonio, Blanco, Jerónimo, Ortiz, Angel R., Messeguer, Àngel, Thomson, Timothy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894972/
https://ncbi.nlm.nih.gov/pubmed/20613989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011403
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