Soluble recombinant human metapneumovirus G protein is immunogenic but not protective

Human metapneumovirus (HMPV) expresses the major surface glycoproteins F and G. We evaluated the protective efficacy of immunization with G. We generated a recombinant form of G ectodomain (GΔTM) that was secreted from mammalian cells and purified by affinity chromatography. We tested the immunogeni...

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Hauptverfasser: Ryder, Alex B., Tollefson, Sharon J., Podsiad, Amy B., Johnson, Joyce E., Williams, John V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894472/
https://ncbi.nlm.nih.gov/pubmed/20417260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.04.007
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