Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1

The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion and cell migration, processes that require the coordinated regulation of actin and microtubule dynamics. APC localizes in vivo to microtubule plus ends and actin-rich cortical protrusions, and has well-documented...

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Autors principals: Okada, Kyoko, Bartolini, Francesca, Deaconescu, Alexandra M., Moseley, James B., Dogic, Zvonimir, Grigorieff, Nikolaus, Gundersen, Gregg G., Goode, Bruce L.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894447/
https://ncbi.nlm.nih.gov/pubmed/20566685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201001016
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