Xeroderma Pigmentosum p48 Gene Enhances Global Genomic Repair and Suppresses UV-Induced Mutagenesis

UV-damaged DNA-binding activity (UV-DDB) is deficient in some xeroderma pigmentosum group E individuals due to mutation of the p48 gene, but its role in DNA repair has been obscure. We found that UV-DDB is also deficient in cell lines and primary tissues from rodents. Transfection of p48 conferred U...

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Hlavní autoři: Tang, Jean Y., Hwang, Byung Joon, Ford, James M., Hanawalt, Philip C., Chu, Gilbert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894271/
https://ncbi.nlm.nih.gov/pubmed/10882109
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