Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells

Global DNA hypomethylation is a hallmark of cancer cells, but its molecular mechanisms have not been elucidated. Here, we show that the disruption of Dnmt1/PCNA/UHRF1 interactions promotes a global DNA hypomethylation in human gliomas. We then demonstrate that the Dnmt1 phosphorylations by Akt and/o...

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Detalhes bibliográficos
Principais autores: Hervouet, Eric, Lalier, Lisenn, Debien, Emilie, Cheray, Mathilde, Geairon, Audrey, Rogniaux, Hélène, Loussouarn, Delphine, Martin, Stéphane A., Vallette, François M., Cartron, Pierre-François
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894052/
https://ncbi.nlm.nih.gov/pubmed/20613874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011333
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