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MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma

Matrix metalloproteinases (MMPs) such as MMP13 promote tumour growth and progression by mediating extracellular matrix (ECM) reorganization and regulating the biological activity of cytokines. Using Mmp13−/− mice, we demonstrate an essential role of this single collagenase for highly malignant and i...

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Bibliografiske detaljer
Main Authors: Lederle, Wiltrud, Hartenstein, Bettina, Meides, Alice, Kunzelmann, Heike, Werb, Zena, Angel, Peter, Mueller, Margareta M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893794/
https://ncbi.nlm.nih.gov/pubmed/19892798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp248
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