Basic Fibroblast Growth Factor Accelerates Matrix Degradation Via a Neuro-Endocrine Pathway in Human Adult Articular Chondrocytes

Pain-related neuropeptides released from synovial fibroblasts, such as substance P, have been implicated in joint destruction. Substance P-induced inflammatory processes are mediated via signaling through a G-protein-coupled receptor, that is, neurokinin-1 tachykinin receptor (NK(1)-R). We determine...

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Main Authors: IM, HEE-JEONG, LI, XIN, MUDDASANI, PRASUNA, KIM, GUN-HEE, DAVIS, FRANCESCA, RANGAN, JAYANTHI, FORSYTH, CHRISTOPHER B., ELLMAN, MICHAEL, THONAR, EUGENE JMA
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893571/
https://ncbi.nlm.nih.gov/pubmed/17960584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21317
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