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Design, conduct, and analyses of Breast International Group (BIG) 1-98: A randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer

BACKGROUND: Aromatase inhibitors provide superior disease control when compared with tamoxifen as adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer. PURPOSE: To present the design, history, and analytic challenges of the Breast International Group (BIG) 1-98 tri...

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Detalhes bibliográficos
Main Authors: Giobbie-Hurder, Anita, Price, Karen N, Gelber, Richard D
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893024/
https://ncbi.nlm.nih.gov/pubmed/19528136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774509105380
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