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Design, conduct, and analyses of Breast International Group (BIG) 1-98: A randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer
BACKGROUND: Aromatase inhibitors provide superior disease control when compared with tamoxifen as adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer. PURPOSE: To present the design, history, and analytic challenges of the Breast International Group (BIG) 1-98 tri...
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Format: | Artigo |
Jezik: | Inglês |
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2009
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893024/ https://ncbi.nlm.nih.gov/pubmed/19528136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774509105380 |
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