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A Molecular Description of Flexibility in an Antibody Combining Site

Mature antibodies (Abs) that are exquisitely specific for virtually any foreign molecule may be produced by affinity maturation of naïve (or germline) Ab. However, the finite number of germline Ab available suggests that, in contrast to mature Ab, germline Ab must be broadly polyspecific so that the...

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Detalhes bibliográficos
Main Authors: Zimmermann, Jörg, Romesberg, Floyd E., Brooks, Charles L., Thorpe, Ian F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892760/
https://ncbi.nlm.nih.gov/pubmed/20455589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp906421v
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