The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

Opa1 modulates mitochondrial fusion, cristae structure and apoptosis. The relationships between these functions and autosomal dominant optic atrophy, caused by mutations in Opa1, are poorly defined. We show that Bnip3 interacts with Opa1, leading to mitochondrial fragmentation and apoptosis. Fission...

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Detalhes bibliográficos
Main Authors: Landes, Thomas, Emorine, Laurent J, Courilleau, Delphine, Rojo, Manuel, Belenguer, Pascale, Arnauné-Pelloquin, Laetitia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892319/
https://ncbi.nlm.nih.gov/pubmed/20436456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.50
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