The extracellular domain of Smoothened regulates ciliary localisation and is required for maximal Hh pathway activation in zebrafish

Members of the Hedgehog (Hh) family of secreted proteins function as morphogens to pattern developing tissues and control cell proliferation. The seven transmembrane domain (7TM) protein Smoothened (Smo) is essential for the activation of all levels of Hh signalling. However, the mechanisms by which...

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Bibliografski detalji
Glavni autori: Aanstad, Pia, Santos, Nicole, Corbit, Kevin C., Scherz, Paul J., Trinh, Le A., Salvenmoser, Willi, Huisken, Jan, Reiter, Jeremy F., Stainier, Didier Y.R.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892286/
https://ncbi.nlm.nih.gov/pubmed/19464178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.04.053
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