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Nitration of the tumor suppressor protein, p53, at tyrosine 327 promotes p53 oligomerization and activation
Previous studies demonstrate that nitric oxide (NO) promotes p53 transcriptional activity by a classical DNA-damage-responsive mechanism involving activation of ATM/ATR and phosphorylation of p53. These studies intentionally used high doses of NO-donors to achieve the maximum DNA-damage. However, lo...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892261/ https://ncbi.nlm.nih.gov/pubmed/20499882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100564w |
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