The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism

Extracellular nucleotides (e.g. ATP, UTP, ADP) are released by activated endothelium, leukocytes and platelets within the injured vasculature and bind specific cell-surface type-2 purinergic (P2) receptors. This process drives vascular inflammation and thrombosis within grafted organs. Importantly,...

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Main Authors: Beldi, Guido, Enjyoji, Keiichi, Wu, Yan, Miller, Lindsay, Banz, Yara, Sun, Xiaofeng, Robson, Simon C.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892180/
https://ncbi.nlm.nih.gov/pubmed/17981736
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