Characterization of prostaglandin E(2) generation through the cyclooxygenase (COX)-2 pathway in human neutrophils

In the present study, we characterized the generation of prostaglandin (PG)E(2) in human neutrophils. We found that the Ca(2+)-dependent type IV cytosolic phospholipase A(2) (cPLA(2)) was pivotally involved in the COX-2-mediated generation of PGE(2) in response to a calcium ionophore, as determined...

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Detalhes bibliográficos
Main Authors: St-Onge, Mireille, Flamand, Nicolas, Biarc, Jordane, Picard, Serge, Bouchard, Line, Dussault, Andrée-Anne, Laflamme, Cynthia, James, Michael J., Caughey, Gillian E., Cleland, Leslie G., Borgeat, Pierre, Pouliot, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891965/
https://ncbi.nlm.nih.gov/pubmed/17643350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2007.06.002
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