EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity

Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests that ESX1 might act primarily by destabilizing the phagosomal membrane that sur...

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Main Authors: Garces, Alejandra, Atmakuri, Krishnamohan, Chase, Michael R., Woodworth, Joshua S., Krastins, Bryan, Rothchild, Alissa C., Ramsdell, Talia L., Lopez, Mary F., Behar, Samuel M., Sarracino, David A., Fortune, Sarah M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891827/
https://ncbi.nlm.nih.gov/pubmed/20585630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000957
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