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Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback that Sustains Endothelial Inflammation

RATIONALE: The extracellular matrix protein, fibronectin (FN), is focally deposited in regions of atherosclerosis where it contributes to inflammatory signaling. OBJECTIVE: To elucidate the mechanism by which FN deposition is regulated by local shear stress patterns, its dependence on PECAM-1 mechan...

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Detalles Bibliográficos
Main Authors: Feaver, Ryan E., Gelfand, Bradley D., Wang, Chong, Schwartz, Martin A., Blackman, Brett R.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891748/
https://ncbi.nlm.nih.gov/pubmed/20378855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.216283
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