Reduced evolvability of Escherichia coli MDS42, an IS-less cellular chassis for molecular and synthetic biology applications

BACKGROUND: Evolvability is an intrinsic feature of all living cells. However, newly emerging, evolved features can be undesirable when genetic circuits, designed and fabricated by rational, synthetic biological approaches, are installed in the cell. Streamlined-genome E. coli MDS42 is free of mutat...

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Bibliografski detalji
Glavni autori: Umenhoffer, Kinga, Fehér, Tamás, Balikó, Gabriella, Ayaydin, Ferhan, Pósfai, János, Blattner, Frederick R, Pósfai, György
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891674/
https://ncbi.nlm.nih.gov/pubmed/20492662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-9-38
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